The Advanced Light Microscopy Technology Platform (ALM) of the Max-Delbrück-Center (MCD) for Molecular Medicine, Berlin-Buch provides scientific support for research groups from MDC and from the associated Berlin Institute for Medical Systems Biology (BIMBS) and the Experimental and Clinical Research Center (ECRC), but allows also external users access to state of the art, high-end imaging techniques. ALM supports the research projects of the scientific groups with customised methodological expertise. ALM currently hosts 15 different high-end microscope systems covering confocal laser scanning microscopy, two-photon microscopy, wide-field fluorescence microscopy, TIRF microscopy, light-sheet microscopy, laser-assisted microdissection. These advanced imaging techniques can be applied to the study of a wide range of samples, from fixed specimens to live cells, tissue preparations, small organisms and animals. Advanced image analysis and processing tools as well as wet lab space and cell culture possibilities are available. Regular seminars covering the basics of light and fluorescence microscopy are offered. In addition to teaching theoretical and practical aspects of light microscopy to ALM users and assuring optimal performance of the instrumentation, we offer collaborative imaging projects tailored for individual user support covering a wide range of expertise, i.e. project planning, optimisation of sample preparation and image acquisition conditions as well as customised image analysis or establishment of imaging methods.