The Electron Microscopy Core Facility (EMcore) offers researchers the use of a wide range of transmission and scanning electron microscopy methods (TEM, SEM). The participating institutions are the Institute for Disease Modeling and Targeted Medicine (IMITATE) and the Institute for Anatomy and Cell Biology. The EMcore is available to both the scientists of the institutes and external groups. Together with the users, we determine the appropriate method for answering their questions and offer the entire EM workflow as a full service: Sample preparation, fixation, preparation and recording of the data. For more work-intensive projects, we instruct the users on the devices so that they can work independently. In addition to classic electron microscopy (TEM, SEM), other methods such as cryopreparation techniques (cryosubstitution, cryo-ultramicrotomy), immune EM, serial block area scanning electron microscopy (SBF-SEM), array tomography scanning electron microscopy and electron tomography are offered.