The Proteomics Platform Core Facility (ProtCF) is located at the Institute of Surgical Pathology (IKP) in Freiburg and supports mass spectrometry-based proteomics research. ProtCF handles projects from the Faculty of Medicine at the University of Freiburg, other university faculties, and external research collaborations. In addition to offering pure measurement services using state-of-the-art mass spectrometry methods, ProtCF also provides, upon request, support and execution of experimental design, sample preparation, measurement, data analysis, biostatistics, and data interpretation. The standard range of services includes: gel-free proteome analysis using Data Independent Acquisition (DIA) or Data Dependent Acquisition (DDA), co-immunoprecipitation (Co-IP) analyses, quantitative proteome comparisons using both label-free and label-based quantification methods (e.g., TMT), identification of post-translational modifications, identification of protease cleavage sites using N-terminomics, identification of proteins from gel bands, targeted proteomics, and proteomic analysis of a wide variety of sample types including cells from tissue culture, tissue from animal models, patient material (fresh tissue, urine, blood serum, liquor), cryo-conserved tissue, formalin-fixed-paraffin embedded tissue, and more.