The Core Unit Systems Medicine is a facility of the medical faculty of the University of Würzburg and the Interdisciplinary Center for Clinical Research (IZKF) of the University Hospital of Würzburg. The CU Systems Medicine enables researchers to apply high-throughput technologies for tackling systems biological and systems medical questions. Currently, the CU Systems Medicine consists of established sub-units for support and execution of diverse genomic analyses - particularly "next-generation sequencing" - and associated bioinformatic data analysis. Key activities of the CU Systems Medicine comprise basic research-oriented functional genomics research projects as well as medically-oriented projects. A particular focus of the CU Systems Medicine lies on development and application of highly parallel molecular single-cell analyses. Further sub-units, in particular for the support of systems biological data analyses and modelling using integration of various data sets (diagnostic markers, proteomic or metabolomic data sets) are in preparation.