Biomaterial plays an important role in biomedical research. The quality of the biomaterials is particularly important for meaningful results. A high quality of biomaterials can often only be provided by specialized large biobanks.In 2012 the Hanover Medical School (MHH) founded the Hannover Unified Biobank (HUB) as the central, uniform biobank of MHH. HUB's goal is to build up a modern, highly automated and standardized biobank, thus enabling the entire MHH as well as external partners an advanced and innovative biobanking. In addition to a modern biobank repository, a standardized, automated sample processing and a professional data management system were developed. Standardization and automation as the basis for a modern, quality-assured, centralized biobank, the HUB is equipped with state-of-the-art biobank infrastructure, such as temperature monitoring, oxygen control, air conditioning, automated repository, storage in liquid nitrogen tanks, emergency power supply and a central Biobank Information Managements System (BIMS). The HUB has been DIN ISO 9001 certified since 2015 and adheres to national and international guidelines for biobanking. A data protection concept, a positive ethics votum, a pseudonymization tool, selected access rights to the samples, a governance structure and its own by laws regulate the legal and ethical framework. There is also close co-operation with other national and international biobanks, which build a common sample and data exchange and adapt their approach and quality standard.